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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MDH1B
All Species:
24.24
Human Site:
Y239
Identified Species:
44.44
UniProt:
Q5I0G3
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5I0G3
NP_001034934.1
518
58651
Y239
R
V
P
L
C
R
L
Y
G
Y
L
I
E
K
N
Chimpanzee
Pan troglodytes
XP_001138429
518
58619
Y239
R
V
P
L
C
R
L
Y
G
Y
L
I
E
K
N
Rhesus Macaque
Macaca mulatta
XP_001106735
518
58711
Y239
R
V
P
L
C
R
L
Y
G
Y
L
I
E
K
N
Dog
Lupus familis
XP_536042
532
60173
Y239
R
L
P
L
C
R
L
Y
G
Y
L
I
E
K
N
Cat
Felis silvestris
Mouse
Mus musculus
Q5F204
500
56279
Y239
R
V
P
L
C
R
L
Y
G
Y
L
I
E
K
N
Rat
Rattus norvegicus
O88989
334
36465
E75
V
I
A
T
D
K
E
E
V
A
F
K
D
L
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508036
548
61874
Y231
E
M
M
K
C
R
R
Y
G
S
L
I
E
K
N
Chicken
Gallus gallus
Q5ZME2
334
36525
E75
V
I
P
T
D
K
E
E
V
A
F
K
D
L
D
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q08BZ4
447
50254
A188
K
M
E
T
V
D
L
A
I
P
R
L
H
E
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_394487
333
36140
P74
E
V
V
P
T
A
D
P
S
V
A
F
K
N
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001201789
553
61629
Y235
G
C
A
Q
F
A
L
Y
G
R
I
L
N
Q
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q08062
332
35571
T73
L
K
G
V
V
A
T
T
D
V
V
E
A
C
T
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P93819
332
35552
T73
L
K
G
V
V
A
T
T
D
A
V
E
G
C
T
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.4
95.9
77.2
N.A.
69.1
20.6
N.A.
55.8
20.2
N.A.
39.9
N.A.
N.A.
20.2
N.A.
36.8
Protein Similarity:
100
99.6
97.4
87.9
N.A.
82.8
35.5
N.A.
72.4
33.9
N.A.
58.4
N.A.
N.A.
38.4
N.A.
55.1
P-Site Identity:
100
100
100
93.3
N.A.
100
0
N.A.
60
6.6
N.A.
6.6
N.A.
N.A.
6.6
N.A.
20
P-Site Similarity:
100
100
100
100
N.A.
100
26.6
N.A.
66.6
33.3
N.A.
33.3
N.A.
N.A.
13.3
N.A.
40
Percent
Protein Identity:
N.A.
21.8
N.A.
21.2
N.A.
N.A.
Protein Similarity:
N.A.
35.7
N.A.
35.9
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
16
0
0
31
0
8
0
24
8
0
8
0
0
% A
% Cys:
0
8
0
0
47
0
0
0
0
0
0
0
0
16
0
% C
% Asp:
0
0
0
0
16
8
8
0
16
0
0
0
16
0
16
% D
% Glu:
16
0
8
0
0
0
16
16
0
0
0
16
47
8
0
% E
% Phe:
0
0
0
0
8
0
0
0
0
0
16
8
0
0
0
% F
% Gly:
8
0
16
0
0
0
0
0
54
0
0
0
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% H
% Ile:
0
16
0
0
0
0
0
0
8
0
8
47
0
0
0
% I
% Lys:
8
16
0
8
0
16
0
0
0
0
0
16
8
47
0
% K
% Leu:
16
8
0
39
0
0
54
0
0
0
47
16
0
16
0
% L
% Met:
0
16
8
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
47
% N
% Pro:
0
0
47
8
0
0
0
8
0
8
0
0
0
0
8
% P
% Gln:
0
0
0
8
0
0
0
0
0
0
0
0
0
8
0
% Q
% Arg:
39
0
0
0
0
47
8
0
0
8
8
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
8
8
0
0
0
0
0
% S
% Thr:
0
0
0
24
8
0
16
16
0
0
0
0
0
0
16
% T
% Val:
16
39
8
16
24
0
0
0
16
16
16
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
54
0
39
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _